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bioRxiv · 10.1101/524900

Domain-specific working memory, but not dopamine-related genetic variability, shapes reward-based motor learning

Codol, O.·Holland, P. J.·Oxley, E.·Taylor, M.·Hamshere, E.·Joseph, S.·Huffer, L.·Galea, J. M.
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Abstract

The addition of rewarding feedback to motor learning tasks has been shown to increase the retention of learning, spurring interest in the possible utility for rehabilitation. However, laboratory-based motor tasks employing rewarding feedback have repeatedly been shown to lead to great inter-individual variability in performance. Understanding the causes of such variability is vital for maximising the potential benefits of reward-based motor learning. Thus, in this pre-registered study, we assessed whether spatial (SWM), verbal (VWM) and mental rotation (RWM) working memory capacity as well as dopamine-related genetic profiles could predict performance in two reward-based motor tasks, using a large cohort of participants (N=241). The first task assessed participants ability to follow a hidden and slowly shifting reward region based on hit/miss (binary) feedback. The second task investigated participants capacity to preserve performance with binary feedback after adapting to the shift with full visual feedback. Our results demonstrate that SWM strongly predicts a participants capacity to reliably reproduce a successful motor action, measured as change in reach angle following reward, while RWM predicted a participants propensity to express an explicit strategy when required to make large adjustments in reach angle. Therefore, both SWM and RWM were reliable predictors of success during reward-based motor learning. Change in reach direction following failure was also a strong predictor of success rate, although we observed no consistent relationship with any type of working memory. Surprisingly, no dopamine-related genotypes predicted performance. Therefore, working memory capacity plays a pivotal in determining individual ability in reward-based motor learning.\n\nSignificance statementReward-based motor learning tasks have repeatedly been shown to lead to idiosyncratic behaviours that cause varying degrees of task success. Yet, the factors determining an individuals capacity to use reward-based feedback are unclear. Here, we assessed a wide range of possible candidate predictors, and demonstrate that domain-specific working memory plays an essential role in determining individual capacity to use reward-based feedback. Surprisingly, genetic variations in dopamine availability were not found to play a role. This is in stark contrast with seminal work in the reinforcement and decision-making literature, which show strong and replicated effects of the same dopaminergic genes in decision-making. Therefore, our results provide novel insights in reward-based motor learning, highlighting a key role for domain-specific working memory capacity.

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Codol, O., Holland, P. J., Oxley, E., Taylor, M., Hamshere, E., Joseph, S., Huffer, L., Galea, J. M.. 2019-01-18. Domain-specific working memory, but not dopamine-related genetic variability, shapes reward-based motor learning. https://doi.org/10.1101/524900

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