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bioRxiv · 10.1101/516096

Sarcopenia is an independent predictor of hospitalization in chronic kidney disease outpatients

Jeong, H. Y.·Ahn, W.·Kim, J. C.·Choi, Y. B.·Kim, J.·Jun, H. H.·Lee, S.·Yang, D. H.·Oh, J.·Bae, J.·Lee, S.-Y.
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Abstract

BackgroundPatients with chronic kidney disease (CKD) experience much more marked and earlier muscle wasting than subjects who do not have chronic illnesses. However, a few studies that have examined sarcopenia have been reported in CKD patients. We investigated the prevalence of sarcopenia in predialysis and dialysis outpatients with CKD and explored its relationship with the clinical outcomes.\n\nMeasurementsSarcopenia was defined as reduced muscle strength accompanied by decreased adjusted appendicular skeletal muscle (ASM), while those patients who exhibited only one of these characteristics were categorized as presarcopenic patients. ASM was measured by bioimpedence analysis, and muscle strength was evaluated by handgrips. ASM was adjusted by weight (ASM/wt). Patients were prospectively followed for up to 2 years.\n\nResultsOne hundred seventy-nine patients were recruited (114 male and 65 female patients who were classified into 103 predialysis patients and 76 dialysis patients, with 44.7% having diabetes). Their mean age was 60.6 {+/-} 13.5 years old. The prevalence of sarcopenia was 9.5%, while 55.9% of the patients were categorized as presarcopenic. The ASM/wt index showed significant correlations with age, handgrip strength, HOMA-IR and frailty scores. Multivariate Cox proportional hazards models demonstrated that the risk of hospitalization was significantly higher for patients with presarcopenia [hazard ratio (HR), 2.48; 95% confidence interval (CI), 1.180-5.230], and the risk of hospitalization was much higher for patients with sarcopenia than for patients in the nonsarcopenic group (HR, 9.11; 95% CI, 2.295-25.182)\n\nConclusionsSarcopenia and presarcopenia, which were defined using the ASM/wt index and handgrip strength, predicted a poorer, hospitalization-free survival in CKD patients

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Jeong, H. Y., Ahn, W., Kim, J. C., Choi, Y. B., Kim, J., Jun, H. H., Lee, S., Yang, D. H., Oh, J., Bae, J., Lee, S.-Y.. 2019-01-09. Sarcopenia is an independent predictor of hospitalization in chronic kidney disease outpatients. https://doi.org/10.1101/516096

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