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bioRxiv · 10.1101/503953

The importance of selected markers of inflammation and blood-brain barrier damage for short-term post-stroke prognosis

Lasek-Bal, A.·Jedrzejowska-Szypułka, H.·Student, S.·Warsz-Wianecka, A.·Zareba, K.·Puz, P.·Bal, W.·Pawletko, K.·Lewin-Kowalik, J.
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Abstract

Background Background Methods Results Discussion Limitations Conclusions The Conflict of Interest... References Stroke causes an immediate local immuno-inflammatory reaction. It is characterized by a strong activation of microglia, astrocytes and vascular endothelial cells; an inflow of inflammatory cells (primarily neutrophils, then macrophages and monocytes); an activation of adhesive molecules and the release of cytokines both from activated cells and the endothelium. Following brain ischemia, a non-specific response is triggered, resulting in the elimination of dead cells from the damage zone and in the protection of surviving neurons from excitotoxicity. In a later stage, specific response mechanisms are activated; these are significant for the regeneration and neurop ...

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Lasek-Bal, A., Jedrzejowska-Szypułka, H., Student, S., Warsz-Wianecka, A., Zareba, K., Puz, P., Bal, W., Pawletko, K., Lewin-Kowalik, J.. 2018-12-21. The importance of selected markers of inflammation and blood-brain barrier damage for short-term post-stroke prognosis. https://doi.org/10.1101/503953

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