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bioRxiv · 10.1101/497255

BetaScan2: Standardized statistics to detect balancing selection utilizing substitution data

Siewert, K. M.·Voight, B. F.
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Abstract

The recently reported statistic {beta} detects balanced haplotypes without the need for genomic data from an outgroup species. Here we present an extension to the method that incorporates between-species substitution data into the {beta} statistic framework. We show that this approach outperforms existing summary statistics in simulations. We also present the variance of {beta} with and without substitution data, allowing calculation of a standardized score. Besides providing a measure of significance, this enables a proper comparison of {beta} values across varying underlying parameters, a feature lacking from some related methods.

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Siewert, K. M., Voight, B. F.. 2018-12-17. BetaScan2: Standardized statistics to detect balancing selection utilizing substitution data. https://doi.org/10.1101/497255

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