The autism and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity

Dominguez-Iturza, N.; Shah, D.; Vannelli, A.; Lo, A. C.; Armendariz, M.; Li, K. W.; Mercaldo, V.; Trusel, M.; Gastaldo, D.; Mameli, M.; Van der Linden, A.; Smit, A. B.; Achsel, T.; Bagni, C.

doi:10.1101/477174

bioRxiv · 10.1101/477174

The autism and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity

Dominguez-Iturza, N.·Shah, D.·Vannelli, A.·Lo, A. C.·Armendariz, M.·Li, K. W.·Mercaldo, V.·Trusel, M.·Gastaldo, D.·Mameli, M.·Van der Linden, A.·Smit, A. B.·Achsel, T.·Bagni, C.

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Abstract

Copy-number variants of the CYFIP1 gene in humans have been linked to Autism and Schizophrenia, two neuropsychiatric disorders characterized by defects in brain connectivity. CYFIP1 regulates molecular events underlying post-synaptic functions. Here, we show that CYFIP1 plays an important role in brain functional connectivity and callosal functions. In particular, we find that Cyfip1 heterozygous mice have reduced brain functional connectivity and defects in white matter architecture, typically relating to phenotypes found in patients with Autism, Schizophrenia and other neuropsychiatric disorders. In addition, Cyfip1 deficient mice present deficits in the callosal axons, namely reduced myelination, altered pre-synaptic function, and impaired bilateral-connectivity related behavior. Altogether, our results show that Cyfip1 haploinsufficiency compromises brain connectivity and function, which might explain its genetic association to neuropsychiatric disorders.

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Dominguez-Iturza, N., Shah, D., Vannelli, A., Lo, A. C., Armendariz, M., Li, K. W., Mercaldo, V., Trusel, M., Gastaldo, D., Mameli, M., Van der Linden, A., Smit, A. B., Achsel, T., Bagni, C.. 2018-11-22. The autism and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity. https://doi.org/10.1101/477174

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