Cryo-EM structure of adenovirus type 3 fibre with desmoglein 2 shows a novel mode of receptor engagement

Vassal-Stermann, E.; Effantin, G.; Zubieta, C.; Burmeister, W. P.; Iseni, F.; Wang, H.; Lieber, A.; Schoehn, G.; Fender, P.

doi:10.1101/471383

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bioRxiv · 10.1101/471383

Cryo-EM structure of adenovirus type 3 fibre with desmoglein 2 shows a novel mode of receptor engagement

Vassal-Stermann, E.·Effantin, G.·Zubieta, C.·Burmeister, W. P.·Iseni, F.·Wang, H.·Lieber, A.·Schoehn, G.·Fender, P.

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Abstract

Attachment of adenovirus (HAd) to host cell is a critical step of infection. This work reports the cryo-electron microscopy (cryo-EM) structure of a non-symmetrical complex smaller than 100kDa formed by the trimeric human adenovirus of type 3 fibre knob (HAd3K) and human desmoglein 2 (DSG2). The structure reveals a unique stoichiometry, shedding light to new adenovirus infection strategies and providing new insights for adenoviral vector development.

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Vassal-Stermann, E., Effantin, G., Zubieta, C., Burmeister, W. P., Iseni, F., Wang, H., Lieber, A., Schoehn, G., Fender, P.. 2018-11-16. Cryo-EM structure of adenovirus type 3 fibre with desmoglein 2 shows a novel mode of receptor engagement. https://doi.org/10.1101/471383

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