Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

Evangelou, E.; Gao, H.; Chu, C.; Ntritsos, G.; Blakeley, P.; Butts, A. R.; Pazoki, R.; Suzuki, H.; Koskeridis, F.; Yiorkas, A. M.; Karaman, I.; Elliott, J.; Aeschbacher, S.; Bartz, T. M.; Baumeister, S. E.; Braund, P. S.; Brown, M. R.; Brody, J. A.; Clarke, T.-K.; Dimou, N.; Faul, J. D.; Homuth, G.; Jackson, A. U.; Kentistou, K. A.; Joshi, P. K.; Lemaitre, R. N.; Lind, P. A.; Lyytikainen, L.-P.; Mangino, M.; Milaneschi, Y.; Nelson, C. P.; Nolte, I. M.; Perala, M.-M.; Polasek, O.; Porteous, D.; Ratliff, S. M.; Smith, J. A.; Stancakova, A.; Teumer, A.; Tuominen, S.; Theriault, S.; Vangipurapu, J

doi:10.1101/453332

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bioRxiv · 10.1101/453332

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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Abstract

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a genome-wide association study (GWAS) of alcohol use in ~480,000 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigated their potential functional significance using magnetic resonance imaging data, gene expression and behavioral studies in Drosophila. Our results identify new genetic pathways associated with alcohol consumption and suggest common genetic mechanisms with several neuropsychiatric disorders including schizophrenia.

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Evangelou, E., Gao, H., Chu, C., Ntritsos, G., Blakeley, P., Butts, A. R., Pazoki, R., Suzuki, H., Koskeridis, F., Yiorkas, A. M., Karaman, I., Elliott, J., Aeschbacher, S., Bartz, T. M., Baumeister, S. E., Braund, P. S., Brown, M. R., Brody, J. A., Clarke, T.-K., Dimou, N., Faul, J. D., Homuth, G., Jackson, A. U., Kentistou, K. A., Joshi, P. K., Lemaitre, R. N., Lind, P. A., Lyytikainen, L.-P., Mangino, M., Milaneschi, Y., Nelson, C. P., Nolte, I. M., Perala, M.-M., Polasek, O., Porteous, D., Ratliff, S. M., Smith, J. A., Stancakova, A., Teumer, A., Tuominen, S., Theriault, S., Vangipurapu, J. 2018-10-30. Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders. https://doi.org/10.1101/453332

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