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bioRxiv · 10.1101/444943

Subtraction and division of visual cortical population responses by the serotonergic system

Azimi, Z.·Spoida, K.·Barzan, R.·Wollenweber, P.·Mark, M. D.·Herlitze, S.·Jancke, D.
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Abstract

Normalization is a fundamental operation throughout neuronal systems to adjust dynamic range. In the visual cortex various cell circuits have been identified that provide the substrate for such a canonical function, but how these circuits are orchestrated remains unclear. Here we suggest the serotonergic (5-HT) system as another player involved in normalization. 5-HT receptors of different classes are co-distributed across different cortical cell types, but their individual contribution to cortical population responses is unknown. We combined wide-field calcium imaging of primary visual cortex (V1) with optogenetic stimulation of 5-HT neurons in mice dorsal raphe nucleus (DRN) -- the major hub for widespread release of serotonin across cortex -- in combination with selective 5-HT receptor blockers. While inhibitory (5-HT1A) receptors accounted for subtractive suppression of spontaneous activity, depolarizing (5-HT2A) receptors promoted divisive suppression of response gain. Added linearly, these components led to normalization of population responses over a range of visual contrasts.

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Azimi, Z., Spoida, K., Barzan, R., Wollenweber, P., Mark, M. D., Herlitze, S., Jancke, D.. 2018-10-16. Subtraction and division of visual cortical population responses by the serotonergic system. https://doi.org/10.1101/444943

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