Ceftolozane-tazobactam pharmacokinetics during extracorporeal membrane oxygenation in a lung transplant recipient

Arena, F.; Marchetti, L.; Henrici De Angelis, L.; Maglioni, E.; Contorni, M.; Cassetta, M. I.; Novelli, A.; Rossolini, G.

doi:10.1101/438671

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bioRxiv · 10.1101/438671

Ceftolozane-tazobactam pharmacokinetics during extracorporeal membrane oxygenation in a lung transplant recipient

Arena, F.·Marchetti, L.·Henrici De Angelis, L.·Maglioni, E.·Contorni, M.·Cassetta, M. I.·Novelli, A.·Rossolini, G.

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Abstract

Ceftolozane-tazobactam pharmacokinetics during extracorporeal membrane oxygenation (ECMO) has not been previously studied. In this work we report on the ceftolozane and tazobactam plasmatic levels in a lung transplant recipient during ECMO, treated with ceftolozane-tazobactam (2g/1g, intravenously every 8 h, 1 h infusion) for a Pseudomonas aeruginosa pulmonary infection. Ceftolozane Cmax and Cmin, monitored during 96 hrs, remained above 60 and 20 g/mL, respectively, with optimal drug exposure (100% %TMIC). Tazobactam levels were above 1.9 g/mL.

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Arena, F., Marchetti, L., Henrici De Angelis, L., Maglioni, E., Contorni, M., Cassetta, M. I., Novelli, A., Rossolini, G.. 2018-10-09. Ceftolozane-tazobactam pharmacokinetics during extracorporeal membrane oxygenation in a lung transplant recipient. https://doi.org/10.1101/438671

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