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bioRxiv · 10.1101/421644

Characteristics of a SAR11 strain grown in batch and continuous culture

Abstract

In this study, a strain of SAR11 subgroup IIIa (termed HIMB114) isolated from the tropical Pacific Ocean was grown in seawater-based batch and continuous culture in order to quantify cellular features and metabolism relevant to SAR11 ecology. We report the first direct measurements of cellular elemental quotas for nitrogen (N) and phosphorus (P) for SAR11: 1.4 {+/-} 0.9 fg N and 0.44 {+/-} 0.01 fg P, respectively, that were consistent with the small size of HIMB114 cells (average volume of 0.09 {micro}m3). However, the mean carbon (C) cellular quota of 50 {+/-} 47 fg C was anomalously high, but variable. Rates of phosphate (PO43-) uptake measured from both batch and continuous cultures were exceptionally slow: in chemostats growing at 0.3 d-1, HIMB114 took up 1.1 {+/-} 0.3 amol P cell-1 d-1, suggesting that <30% of the cellular P requirement of HIMB114 was met by PO43- assimilation. The mean rate of leucine incorporation, a measure of bacterial production, during late log phase growth of batch HIMB114 cultures was 0.042 {+/-} 0.02 amol Leu cell-1 h-1. While only weakly correlated with changes in specific growth rates, the onset of stationary phase resulted in decreases in cell-specific leucine incorporation that were proportional to changes in growth rate. Rates of cellular production, respiratory oxygen consumption, and changes in total organic C concentrations constrained cellular growth efficiencies to 13 {+/-} 4%. Hence, despite the small, streamlined genome and diminutively sized cells, SAR11 strain HIMB114 appears to grow at efficiencies similar to naturally occurring bacterioplankton communities.\n\nImportanceWhile SAR11 bacteria contribute a significant fraction to the total picoplankton biomass in the ocean and likely are major players in organic C and nutrient cycling, the cellular characteristics and metabolic features of most lineages have either been only hypothesized from genomes or otherwise not measured in controlled laboratory experimentation. The dearth of data on even the most basic characteristics for what is arguably the most abundant heterotroph in seawater has limited the specific consideration of SAR11 in ocean ecosystem modeling efforts. In this study, we provide measures of cellular P, N, C, aerobic respiration and bacterial production for a SAR11 strain growing in natural seawater media that can be used to directly relate these features of SAR11 to biogeochemical cycling in the oceans. Through the development of a chemostat system to measure nutrient uptake during steady-state growth, we have also documented inorganic P uptake rates that allude to the importance of organic phosphorous to meet cellular P demands, even in the presence of non-limiting PO43- concentrations.

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Grant, S. R., Church, M. J., Ferron, S., Laws, E., Rappe, M.. 2018-09-20. Characteristics of a SAR11 strain grown in batch and continuous culture. https://doi.org/10.1101/421644

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