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bioRxiv · 10.1101/413435

Glutathione S-Transferase Genotype polymorphism and Primary Open-Angle Glaucoma in an Italian population

Sacca, S. C.·Cutolo, C. A.·Gandolfi, S.·Marchini, G.·Quaranta, L.·Izzotti, A.·Rossi, T.·Traverso, C. E.
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Abstract

PurposeOxidative damage to the trabecular meshwork (TM) represents one of the pathogenic mechanisms leading to primary open angle glaucoma (POAG). Glutathione S-transferase mu 1 (GSTM1) may neutralizes reactive oxygen species protecting the TM. The present paper investigates the prevalence of GSTM1 null genotype in an Italian population, and its association with POAG treated either medically or surgically.\n\nMethodsIn a case-control study, the GSTM1 genotype was identified in POAGs and controls. The POAGs patients were divided in two groups: medical POAGs and surgical POAGS. Medical POAGs consisted of patients with a well-controlled intraocular pressure (IOP) by IOP-lowering medications and a stable visual field (VF). Patients with an uncontrolled IOP and a progressing VF that were submitted to incisional surgery formed the surgical POAGs group.\n\nResultsWe enrolled 104 medical POAGs, 158 surgical POAGs and 263 Controls. No significative differences between the groups existed regarding age and gender (p=0.275 and p=0.950, respectively). All the enrolled subjects were Caucasian of Italian descents. The GSTM1 null genotype was identified in 57 (45.2%) medical POAGs, 91 (57.6%) surgical POAGs and, 119 (45.3%) controls (p=0.033). The association between medical POAG and GSTM1 null status was non-significant (OR= 1.44, 95% IC = 0.86 to 2.39) whereas the association was significant for surgical POAGs (OR= 2.01, 95% IC= 1.26 to 3.21)\n\nConclusionsOur results showed an association between the GSTM1 null genotype and glaucoma that require surgery in an Italian population. GSTM1 null genotype detection may help to identify high-risk glaucoma patients that require a closer follow-up and a more aggressive treatments.

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Sacca, S. C., Cutolo, C. A., Gandolfi, S., Marchini, G., Quaranta, L., Izzotti, A., Rossi, T., Traverso, C. E.. 2018-09-10. Glutathione S-Transferase Genotype polymorphism and Primary Open-Angle Glaucoma in an Italian population. https://doi.org/10.1101/413435

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