Distance-dependent consistency thresholds for generating group-representative structural brain networks

Abstract

Large-scale structural brain networks encode white-matter connectivity patterns among distributed brain areas. These connection patterns are believed to support cognitive processes and, when compromised, can lead to neurocognitive deficits and maladaptive behavior. A powerful approach for studying the organizing principles of brain networks is to construct group-representative networks from multi-subject cohorts. Doing so amplifies signal to noise ratios and provides a clearer picture of brain network organization. Here, we show that current approaches for generating grouprepresentative networks over-estimate the proportion of short-range connections present in a network and, as a result, fail to match subject-level networks along a wide range of network statistics. We present an alternative approach that preserves the connection-length distribution of individual subjects. Due to this simple modification, the networks generated using this novel approach successfully recapitulate subject-level properties, outperforming all existing approaches by better preserving features that promote integrative brain function rather than segregative. The method developed here holds promise for future studies investigating basic organizational principles and features of largescale structural brain networks.