Natural alteration of HIV-1 co-receptor tropism by contemporaneous HIV-2 infection 1

Esbjornsson, J.; Mansson, F.; Norrgren, H.; Rowland-Jones, S.

doi:10.1101/410456

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bioRxiv · 10.1101/410456

Natural alteration of HIV-1 co-receptor tropism by contemporaneous HIV-2 infection 1

Esbjornsson, J.·Mansson, F.·Norrgren, H.·Rowland-Jones, S.

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Abstract

In this study, we show that the pathogenic HIV-1 CXCR4-tropism is more common in HIV-1 single (79%) than in HIV-1 and HIV-2 dual-infected individuals (35%), suggesting that contemporaneous HIV-2 infection can affect HIV-1 co-receptor tropism in late-stage disease. Understanding the underlying mechanisms responsible for this natural alteration by HIV-2 could pave the way towards a deeper understanding of the AIDS pathogenesis.

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Esbjornsson, J., Mansson, F., Norrgren, H., Rowland-Jones, S.. 2018-09-07. Natural alteration of HIV-1 co-receptor tropism by contemporaneous HIV-2 infection 1. https://doi.org/10.1101/410456

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