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bioRxiv · 10.1101/403311

Aquaporin-4 facilitator TGN-073 demonstrates novel analgesic activity

Huber, V. J.·Kwee, I. L.·Nakada, T.
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Abstract

During pre-clinical development, we tested the novel, internally developed AQP-4 facilitator TGN-073 for its effect in a rodent pain model. Therein, TGN-073 was found to exert a strong analgesic effect. Following a single 200 mg/kg (i.p.) administration of TGN-073, a virtually complete block in the acetic acid writhing test was observed. Subsequent in vitro tests demonstrated that TGN-073 had no binding affinity for the -opioid or NK-1 receptors. Accordingly, we suspect TGN-073 or other AQP-4 facilitators may be developed into potent non-opioid analgesic agents. Given the potential significance of this discovery, we feel it should be openly shared with the scientific community.

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Huber, V. J., Kwee, I. L., Nakada, T.. 2018-10-08. Aquaporin-4 facilitator TGN-073 demonstrates novel analgesic activity. https://doi.org/10.1101/403311

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