Hierarchical composition of reliable recombinase logic devices.

Guiziou, S.; Mayonove, P.; Bonnet, J.

doi:10.1101/390823

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bioRxiv · 10.1101/390823

Hierarchical composition of reliable recombinase logic devices.

Guiziou, S.·Mayonove, P.·Bonnet, J.

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Abstract

We provide a systematic framework for engineering reliable recombinase logic devices by hierarchical composition of well-characterized, optimized recombinase switches. We apply this framework to build a recombinase logic device family supporting up to 4-input Boolean logic. This work will support the predictable engineering of several classes of recombinase devices to reliably control cellular behavior.

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Guiziou, S., Mayonove, P., Bonnet, J.. 2018-08-13. Hierarchical composition of reliable recombinase logic devices.. https://doi.org/10.1101/390823

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