Test-Retest Reliability of Task-based and Resting-state Blood Oxygen Level Dependence and Cerebral Blood Flow measures

Holiga, S.; Sambataro, F.; Lucy, C.; Greig, G.; Sarkar, N.; Renken, R. J.; Marsman, J.-B. C.; Schobel, S. A.; Bertolino, A.; Dukart, J.

doi:10.1101/381251

bioRxiv · 10.1101/381251

Test-Retest Reliability of Task-based and Resting-state Blood Oxygen Level Dependence and Cerebral Blood Flow measures

Holiga, S.·Sambataro, F.·Lucy, C.·Greig, G.·Sarkar, N.·Renken, R. J.·Marsman, J.-B. C.·Schobel, S. A.·Bertolino, A.·Dukart, J.

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Abstract

Despite their wide-spread use, only limited information is available on the comparative test-retest reliability of task-based functional and resting state magnetic resonance imaging measures of blood oxygen level dependence (tb-fMRI and rs-fMRI) and cerebral blood flow (CBF) using arterial spin labeling. This information is critical to designing properly powered longitudinal studies. Here we comprehensively quantified and compared the test-retest reliability and reproducibility performance of 8 commonly applied fMRI tasks, 6 rs-fMRI metrics and CBF in 30 healthy volunteers. We find large variability in test-retest reliability performance across the different tb-fMRI paradigms and rs-fMRI metrics, ranging from poor to excellent. A larger extent of activation in tb-fMRI is linked to higher between-subject reliability of the respective task suggesting that differences in the amount of activation may be used as a first reliability estimate of novel tb-fMRI paradigms. For rs-fMRI, a good reliability of local activity estimates is paralleled by poor performance of global connectivity metrics. Evaluated CBF measures provide in general a good to excellent test-reliability matching or surpassing the best performing tb-fMRI and rs-fMRI metrics. This comprehensive effort allows for direct comparisons of test-retest reliability between the evaluated MRI domains and measures to aid the design of future tb-fMRI, rs-fMRI and CBF studies.

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Holiga, S., Sambataro, F., Lucy, C., Greig, G., Sarkar, N., Renken, R. J., Marsman, J.-B. C., Schobel, S. A., Bertolino, A., Dukart, J.. 2018-07-31. Test-Retest Reliability of Task-based and Resting-state Blood Oxygen Level Dependence and Cerebral Blood Flow measures. https://doi.org/10.1101/381251

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