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bioRxiv · 10.1101/371864

Maternal immunity and antibodies to dengue promote Zika virus-induced microcephaly in fetuses

Rathore, A. P. S.·Saron, W. A. A.·Lim, T.·Jahan, N.·St. John, A.
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Abstract

Zika virus (ZIKV), a recently emerged flaviviral pathogen, has been linked to microcephaly in neonates1. Yet, it is not understood why some fetuses develop severe microcephaly due to maternal ZIKV infection while others do not. The risk for ZIKV-induced microcephaly is greatest during the first trimester of pregnancy in humans2,3, yet this alone cannot account for the varied presentation of microcephaly observed. Given the antigenic similarity between ZIKV and closely related dengue virus (DENV)4, combined with the substantial immunity to DENV in ZIKV target populations in recent outbreaks, we hypothesized that maternal antibodies against DENV could promote ZIKV-induced microcephaly. Here, using immune-competent mice, we show that maternal to fetal transmission of ZIKV occurs, leading to fetal infection and disproportionate microcephaly. DENV-specific antibodies in pregnant female mice enhance vertical transmission of infection and result in a severe microcephaly like-syndrome during ZIKV infection. Furthermore, fetal infection was promoted by the neonatal Fc receptor (FcRN). Our results identify a novel immune-mediated mechanism of vertical transmission of viral infection and raise caution since ZIKV epidemic regions are also endemic to DENV.

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Rathore, A. P. S., Saron, W. A. A., Lim, T., Jahan, N., St. John, A.. 2018-07-18. Maternal immunity and antibodies to dengue promote Zika virus-induced microcephaly in fetuses. https://doi.org/10.1101/371864

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