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bioRxiv · 10.1101/363820

Restoring memory by optogenetic synchronization of hippocampal oscillations in an Alzheimer’s disease mouse model

Ambrad Giovannetti, E.·Poll, S.·Justus, D.·Kaneko, H.·Fuhrmann, F.·Steffen, J.·Remy, S.·Fuhrmann, M.
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Abstract

Disrupted neural oscillations are a feature of Alzheimers disease (AD). We observed reduced frequency of theta oscillations in the hippocampal local field potential (LFP) in a mouse model of beta-amyloidosis. By restoring the temporal organization of theta oscillations using LFP-guided closed-loop optogenetic stimulation of parvalbumin-positive interneurons, we could rescue memory deficits of APP/PS1 mice in the novel object recognition test.

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Ambrad Giovannetti, E., Poll, S., Justus, D., Kaneko, H., Fuhrmann, F., Steffen, J., Remy, S., Fuhrmann, M.. 2018-11-09. Restoring memory by optogenetic synchronization of hippocampal oscillations in an Alzheimer’s disease mouse model. https://doi.org/10.1101/363820

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