Molecular Complexes for Effective Inhibition of Tau Aggregation

Gorantla, N. V.; Landge, V. G.; Nagaraju, P. G.; Sunny, L. P.; Nair, A.; Midya, S. P.; Priyadarshini, P.; Ekambaram, B.; Chinnathambi, S.

doi:10.1101/363572

bioRxiv · 10.1101/363572

Molecular Complexes for Effective Inhibition of Tau Aggregation

Gorantla, N. V.·Landge, V. G.·Nagaraju, P. G.·Sunny, L. P.·Nair, A.·Midya, S. P.·Priyadarshini, P.·Ekambaram, B.·Chinnathambi, S.

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Abstract

Tau is an axonal protein known to form abnormal aggregates and is the biomarker of Alzheimers disease. Metal-based therapeutics for inhibition of Tau aggregation is limited and rarely reported in the contemporary science. Here, the first example is reported of a rationally designed molecular cobalt(II)-complexes for effective inhibition of Tau and disaggregation of preformed Tau fibrils. The mechanistic studies revealed that the prevention of Tau aggregation by CBMCs is concentration-dependent and Tau seldom exhibits conformational changes. Interestingly, CBMCs play a dual role by causing disassembly of preformed aggregates as well as complete Tau inhibition. We believe that this unprecedented finding by the newly developed molecular complexes has a potential to lead to developing innovative metal-based therapeutics for Alzheimers disease.

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Gorantla, N. V., Landge, V. G., Nagaraju, P. G., Sunny, L. P., Nair, A., Midya, S. P., Priyadarshini, P., Ekambaram, B., Chinnathambi, S.. 2018-07-06. Molecular Complexes for Effective Inhibition of Tau Aggregation. https://doi.org/10.1101/363572

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