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bioRxiv · 10.1101/351940

Antibiotic-driven Escape of Host in a Parasite-induced Red Queen Dynamics

Rabajante, J. F.·Anzia, E. L.
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Abstract

Winnerless coevolution of hosts and parasites could exhibit Red Queen dynamics, which is characterized by parasite-driven cyclic switching of expressed host phenotypes. We hypothesize that the application of antibiotics to suppress the reproduction of parasites can provide opportunity for the hosts to escape such winnerless coevolution. Here, we formulate a minimal mathematical model of host-parasite interaction involving multiple host phenotypes that are targeted by adapting parasites. Our model predicts the levels of antibiotic effectiveness that can steer the parasite-driven cyclic switching of host phenotypes (heteroclinic oscillations) to a stable equilibrium of host survival. Our simulations show that uninterrupted application of antibiotic with high-level effectiveness (> 85%) is needed to escape the Red Queen dynamics. Intermittent and low level of antibiotic effectiveness are indeed useless to stop host-parasite coevolution. This study can be a guide in designing good practices and protocols to minimize risk of further progression of parasitic infections.

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Rabajante, J. F., Anzia, E. L.. 2018-06-20. Antibiotic-driven Escape of Host in a Parasite-induced Red Queen Dynamics. https://doi.org/10.1101/351940

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