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bioRxiv · 10.1101/351056

TTL proteins scaffold brassinosteroid signaling components at the plasma membrane to optimize signal transduction in plant cells

Abstract

Brassinosteroids (BRs) form a group of steroidal hormones essential for plant growth, development and stress responses. Here, we report that plant-specific TETRATRICOPEPTIDE THIOREDOXIN-LIKE (TTL) proteins are positive regulators of BR signaling functioning as scaffold for BR signaling components in Arabidopsis. TTL3 forms a complex with all core components involved in BR signaling, including the receptor kinase BRASSINOSTEROID INSENSITIVE1 (BRI1), the transcription factor BRASSINAZOLE RESISTANT1 (BZR1) and the phosphatase BRI1-SUPPRESSOR1 (BSU1), but excluding the co-receptor BAK1. TTL3 is mainly localized in the cytoplasm, but BR treatment increases its localization at the plasma membrane, where it strengthens the association with BR signaling components. Consistent with a role in BR signaling, mutations in TTL3 and related TTL1 and TTL4 genes cause reduced BR responsiveness. We propose a mechanistic model for BR signaling, in which cytoplasmic/nuclear BR components bound to TTL proteins are recruited to the plasma membrane upon BR perception, which in turn allows the assembly of a BR signaling complex, leading to the de-phosphorylation and nuclear accumulation of the transcription factors BZR1 and BES1.

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BibTeXRIS

Amorim-Silva, V., Garcia-Moreno, A., Castillo, A. G., Lakhssassi, N., Perez-Sancho, J., Li, Y., Esteban del Valle, A., Pose, D., Perez-Rodriguez, J., Lin, J., Valpuesta, V., Borsani, O., Zipfel, C., Macho, A. P., Botella, M. A.. 2018-06-20. TTL proteins scaffold brassinosteroid signaling components at the plasma membrane to optimize signal transduction in plant cells. https://doi.org/10.1101/351056

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