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bioRxiv · 10.1101/348524

Cell type specific control of basolateral amygdala plasticity via feedforward inhibition

Guthman, E. M.·Ma, M.·Chu, P.·Baca, S. M.·Restrepo, D.·Huntsman, M. M.
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Abstract

The basolateral amygdala (BLA) plays a vital role in associating specific sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this integrated sensory-valence information; however, local BLA inhibitory interneurons (INs) gate the plasticity of the PNs via feed forward inhibition (FFI). Despite extensive literature implicating parvalbumin expressing (PV+) INs in FFI in cortex and hippocampus, prior anatomical experiments in BLA implicate somatostatin expressing (Sst+) INs in BLA. In the present study, we combined patch clamp electrophysiology with chemogenetics, unsupervised cluster analysis, and predictive modeling and found that a previously unreported subpopulation of fast-spiking Sst+ INs mediate BLA FFI and gate plasticity.

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Guthman, E. M., Ma, M., Chu, P., Baca, S. M., Restrepo, D., Huntsman, M. M.. 2018-06-18. Cell type specific control of basolateral amygdala plasticity via feedforward inhibition. https://doi.org/10.1101/348524

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