Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis

Gallagher, C. S.; Makinen, N.; Harris, H. R.; Uimari, O.; Cook, J. P.; Shigesi, N.; Rahmioglu, N.; Ferreira, T.; Velez-Edwards, D. R.; Edwards, T. L.; Ruhioglu, Z.; Day, F.; Becker, C. M.; Karhunen, V.; Martikainen, H.; Jarvelin, M.-R.; Cantor, R. M.; Ridker, P. M.; Terry, K. L.; Buring, J. E.; Gordon, S. D.; Medland, S. E.; Montgomery, G. W.; Nyholt, D. R.; Hinds, D. A.; Tung, J. Y.; the 23andMe Research team,; Perry, J. R. B.; Lind, P. A.; Painter, J. N.; Martin, N. G.; Morris, A. P.; Chasman, D. I.; Missmer, S.; Zondervan, K. T.; Morton, C. C.

doi:10.1101/324905

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bioRxiv · 10.1101/324905

Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis

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Abstract

Uterine leiomyomata (UL), also known as uterine fibroids, are the most common neoplasms of the reproductive tract and the primary cause for hysterectomy, leading to considerable impact on womens lives as well as high economic burden1,2. Genetic epidemiologic studies indicate that heritable risk factors contribute to UL pathogenesis3. Previous genome-wide association studies (GWAS) identified five loci associated with UL at genome-wide significance (P < 5 x 10-8)4-6. We conducted GWAS meta-analysis in 20,406 cases and 223,918 female controls of white European ancestry, identifying 24 genome-wide significant independent loci; 17 replicated in an unrelated cohort of 15,068 additional cases and 43,587 female controls. Aggregation of discovery and replication studies (35,474 cases and 267,505 female controls) revealed six additional significant loci. Interestingly, four of the 17 loci identified and replicated in these analyses have also been associated with risk for endometriosis - another common gynecologic disorder. These findings increase our understanding of the biological mechanisms underlying UL development, and suggest overlapping genetic origins with endometriosis.

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Gallagher, C. S., Makinen, N., Harris, H. R., Uimari, O., Cook, J. P., Shigesi, N., Rahmioglu, N., Ferreira, T., Velez-Edwards, D. R., Edwards, T. L., Ruhioglu, Z., Day, F., Becker, C. M., Karhunen, V., Martikainen, H., Jarvelin, M.-R., Cantor, R. M., Ridker, P. M., Terry, K. L., Buring, J. E., Gordon, S. D., Medland, S. E., Montgomery, G. W., Nyholt, D. R., Hinds, D. A., Tung, J. Y., the 23andMe Research team,, Perry, J. R. B., Lind, P. A., Painter, J. N., Martin, N. G., Morris, A. P., Chasman, D. I., Missmer, S., Zondervan, K. T., Morton, C. C.. 2018-05-18. Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis. https://doi.org/10.1101/324905

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