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bioRxiv · 10.1101/304345

Inhibition of EV71 replication by L3HYPDH, a newly identified interferon-stimulated gene product

Liu, J.·Liu, L.·Shinun Zeng, S.·Meng, X.·Lei, N.·Yang, H.·Li, R.·Guo, X.
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Abstract

Enterovirus 71 (EV71) is the common causative agent of hand-foot-mouth disease (HFMD). Despite evidence in mice model suggested that the interferon (IFN) signaling pathways play a role in defending against this virus, knowledge on the IFN-mediated antiviral response is still limited. Here we identified an IFN-stimulated gene (ISG) called L3HYPHD, whose expression inhibits EV71 replication. Mapping assay indicated that amino acids 61-120 and 295-354 are critical for its optimal antiviral activity. Mechanismly, L3HYPDH specifically inhibits protein translation mediated by EV71 internal ribosome entry site (IRES). Our data thus uncovered a new mechanism utilized by the host cell to restrict EV71 replication.

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Liu, J., Liu, L., Shinun Zeng, S., Meng, X., Lei, N., Yang, H., Li, R., Guo, X.. 2018-04-19. Inhibition of EV71 replication by L3HYPDH, a newly identified interferon-stimulated gene product. https://doi.org/10.1101/304345

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