STREAM: Single-cell Trajectories Reconstruction, Exploration And Mapping of omics data

Chen, H.; Albergante, L.; Hsu, J. Y.; Lareau, C. A.; Lo Bosco, G.; Guan, J.; Zhou, S.; Gorban, A. N.; Bauer, D. E.; Aryee, M. J.; Langenau, D. M.; Zinovyev, A.; Buenrostro, J. D.; Yuan, G.-C.; Pinello, L.

doi:10.1101/302554

bioRxiv · 10.1101/302554

STREAM: Single-cell Trajectories Reconstruction, Exploration And Mapping of omics data

Chen, H.·Albergante, L.·Hsu, J. Y.·Lareau, C. A.·Lo Bosco, G.·Guan, J.·Zhou, S.·Gorban, A. N.·Bauer, D. E.·Aryee, M. J.·Langenau, D. M.·Zinovyev, A.·Buenrostro, J. D.·Yuan, G.-C.·Pinello, L.

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Abstract

Single-cell transcriptomic assays have enabled the de novo reconstruction of lineage differentiation trajectories, along with the characterization of cellular heterogeneity and state transitions. Several methods have been developed for reconstructing developmental trajectories from single-cell transcriptomic data, but efforts on analyzing single-cell epigenomic data and on trajectory visualization remain limited. Here we present STREAM, an interactive pipeline capable of disentangling and visualizing complex branching trajectories from both single-cell transcriptomic and epigenomic data.

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Chen, H., Albergante, L., Hsu, J. Y., Lareau, C. A., Lo Bosco, G., Guan, J., Zhou, S., Gorban, A. N., Bauer, D. E., Aryee, M. J., Langenau, D. M., Zinovyev, A., Buenrostro, J. D., Yuan, G.-C., Pinello, L.. 2018-04-18. STREAM: Single-cell Trajectories Reconstruction, Exploration And Mapping of omics data. https://doi.org/10.1101/302554

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