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bioRxiv · 10.1101/293597

Identifying neural predictors of response to cortical or striatal deep brain stimulation in a rodent model of alcohol drinking: Towards developing individualized therapies for alcohol use disorders

Henricks, A. M.·Dwiel, L. L.·Deveau, N. H.·Simon, A. A.·Green, A. I.·Doucette, W. T.
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Abstract

Individuals differ in their vulnerability to develop alcohol dependence that are determined by innate and environmental factors. The corticostriatal circuit is heavily involved in the development of alcohol dependence and may contain neural information regarding vulnerability to drink excessively. In the current experiment, we hypothesized that we could characterize high and low alcohol-drinking rats (HD and LD, respectively) based on corticostriatal oscillations, and that these subgroups would differentially respond to corticostriatal brain stimulation. Rats were trained to drink 10% alcohol in a limited access paradigm. In separate sessions, local field potentials (LFPs) were recorded from the nucleus accumbens shell (NAcSh) and medial prefrontal cortex (mPFC) of male Sprague-Dawley rats (n=13). Based on training alcohol consumption levels, we classified rats using a median split as HD or LD. Then, using machine-learning, we built predictive models to classify rats as HD or LD by corticostriatal LFPs and compared the model performance from real data to the performance of models built on data permutations. Additionally, we explored the impact of NAcSh or mPFC stimulation on alcohol consumption in HD vs. LD. Corticostriatal LFPs were able predict HD vs. LD group classification with greater accuracy than expected by chance (>80% accuracy). Additionally, NAcSh stimulation significantly reduced alcohol consumption in HD, but not LD (p<0.05), while mPFC stimulation did not alter drinking behavior in either HD or LD (p>0.05). These data collectively show that the corticostriatal circuit is differentially involved in regulating alcohol intake in HD vs. LD rats, and suggests that corticostriatal activity may have the potential to predict a vulnerability to develop alcohol dependence in a clinical population.

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Henricks, A. M., Dwiel, L. L., Deveau, N. H., Simon, A. A., Green, A. I., Doucette, W. T.. 2018-04-02. Identifying neural predictors of response to cortical or striatal deep brain stimulation in a rodent model of alcohol drinking: Towards developing individualized therapies for alcohol use disorders. https://doi.org/10.1101/293597

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