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bioRxiv · 10.1101/293175

RobusTAD: A Tool for Robust Annotation ofTopologically Associating Domain Boundaries

Dali, R.·Bourque, G.·Blanchette, M.
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Abstract

MotivationTopologically Associating Domains (TADs) are chromatin structures that can be identified by analysis of Hi-C data. Tools currently available for TAD identification are sensitive to experimental conditions such as coverage, resolution and noise level.\n\nResultsHere, we present RobusTAD, a tool to score TAD boundaries in a manner that is robust to these parameters. In doing so, RobusTAD eases comparative analysis of TAD structures across multiple heterogeneous samples.\n\nAvailabilityRobusTAD is implemented in R and released under a GPL license. RobusTAD can be downloaded from https://github.com/rdali/RobusTAD and runs on any standard desktop computer.\n\nContactrola.dali@mail.mcgill.ca, blanchem@cs.mcgill.ca\n\nSupplementary informationSupplementary data are available at Bioinformatics online.

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Dali, R., Bourque, G., Blanchette, M.. 2018-04-02. RobusTAD: A Tool for Robust Annotation ofTopologically Associating Domain Boundaries. https://doi.org/10.1101/293175

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