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bioRxiv · 10.1101/290536

Ameliorative potential of curcumin on cigarette smoke extract induced cognitive impairment in zebrafish

Thilagavathi, L.·Jabeen, S.·Ravishankar, S. B.·Ahmed, S. S.·George, T.·Rishitha, N.·Muthuraman, A.·Paramakrishnan, N.
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Abstract

Curcumin is a major phyto-constituent of Curcuma longa. It has been reported that it that it showed various pharmacological actions via anti-oxidant, anti-inflammatory, and immunomodulatory actions. The present study undergoes the therapeutic evaluation of curcumin in cigarette smoke extract (CSE) exposure induced cognitive impairment in zebrafish. Methods: The cognitive impairment was induced by exposure to 25 ml of 200 % CSE; 10 minutes/day, for 7 consecutive days. The pre-treatment of curcumin (10 and 20 mg/kg) and montelukast(20 mg/kg) were exposed in 25 ml drug solution (10 minutes/day for 10 consecutive days). The changes of CSE induced cognitive dysfunction were evaluated by using different test methods such as colour recognition test; partition preference test; horizontal compartment test; and T-Maze tests. Further, the CSE exposure induced changes of biochemical parameters i.e., acetylcholinesterase activity; lipid peroxidation; reduced glutathione; and total protein levels were estimated in the brain of zebrafish. The pre-exposure of curcumin shown to produce the ameliorative effect against CSE induced neurocognitive impairments along with alteration of biochemical changes. Theseresults were comparable to reference control i.e., montelukast pre-treated group. Therefore, the curcumin can be served as newer medicines for immunological reaction associated neurocognitive disorders like Alzheimer and multiple sclerosis due to its potential anti-oxidative; anti-inflammatory; immunomodulatory; and acetylcholinesterase inhibitory actions.\n\nSUMMARYLoss of memory is a major problem in old age population. Curcumin used to treats the various neurological disorders. Curcumin possess the ameliorative potential in toxin induced neurocognitive function.

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Thilagavathi, L., Jabeen, S., Ravishankar, S. B., Ahmed, S. S., George, T., Rishitha, N., Muthuraman, A., Paramakrishnan, N.. 2018-03-28. Ameliorative potential of curcumin on cigarette smoke extract induced cognitive impairment in zebrafish. https://doi.org/10.1101/290536

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