Cortical thickness in right frontal and left lingual gyri differentially mediate episodic memory for spatial contextual details across the adult lifespan

Swierkot, A.; Rajah, M. N.

doi:10.1101/289447

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bioRxiv · 10.1101/289447

Cortical thickness in right frontal and left lingual gyri differentially mediate episodic memory for spatial contextual details across the adult lifespan

Swierkot, A.·Rajah, M. N.

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Abstract

Healthy aging is associated with declines in episodic memory and with widespread cortical thinning. These parallel declines suggest that age-related changes in cortical thickness may contribute to episodic memory decline with age. The current study uses a cross-sectional study design to examine whether regional cortical thickness mediates the relationship between age and episodic memory, as measured by a context memory task for faces. Mediation and conditional mediation models were tested using bootstrapping in order to determine how age-associated changes in regional cortical thickness mediated age-associated changes in performance on the context memory task. We observed that right superior frontal cortical thickness conditionally mediated spatial context memory only in middle-aged and older adults; and right caudal middle frontal cortical thickness conditionally mediated context memory only in older adults. Left lingual cortical thickness mediated spatial context memory across the adult lifespan, but this effect was most evident at midlife. Right parahippocampal cortical thickness mediated context memory, independent of age. We conclude that our cortical thickness results were generally consistent with the posterior-to-anterior shift in aging hypothesis (Davis et al., 2008) for episodic memory.

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Swierkot, A., Rajah, M. N.. 2018-03-27. Cortical thickness in right frontal and left lingual gyri differentially mediate episodic memory for spatial contextual details across the adult lifespan. https://doi.org/10.1101/289447

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