GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology

Bovijn, J.; Jackson, L.; Censin, J.; Chen, C.-Y.; Laisk-Podar, T.; Laber, S.; Ferreira, T.; Glastonbury, C.; Smoller, J.; Harrison, J. W.; Ruth, K. S.; Beaumont, R. N.; Jones, S. E.; Tyrrell, J.; Wood, A. R.; Weedon, M. N.; Mägi, R.; Neale, B.; Lindgren, C. M.; Murray, A.; Holmes, M. V.

doi:10.1101/283002

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bioRxiv · 10.1101/283002

GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology

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Abstract

GWAS of erectile dysfunction (ED) in 6,175 cases among 223,805 European men identified one new locus at 6q16.3 (lead variant rs57989773, OR 1.20 per C-allele; p = 5.71x10-14), located between MCHR2 and SIM1. In-silico analysis suggests SIM1 to confer ED risk through hypothalamic dysregulation; Mendelian randomization indicates genetic risk of type 2 diabetes causes ED. Our findings provide novel insights into the biological underpinnings of ED.

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Bovijn, J., Jackson, L., Censin, J., Chen, C.-Y., Laisk-Podar, T., Laber, S., Ferreira, T., Glastonbury, C., Smoller, J., Harrison, J. W., Ruth, K. S., Beaumont, R. N., Jones, S. E., Tyrrell, J., Wood, A. R., Weedon, M. N., Mägi, R., Neale, B., Lindgren, C. M., Murray, A., Holmes, M. V.. 2018-03-15. GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology. https://doi.org/10.1101/283002

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