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bioRxiv · 10.1101/271171

Membrane proteins with high N-glycosylation, high expression, and multiple interaction partners were preferred by mammalian viruses as receptors

Zhang, Z.·Zhu, Z.·Chen, W.·Cai, Z.·Xu, B.·Tan, Z.·Wu, A.·Ge, X.·Guo, X.·Xia, Z.·Zhu, H.·Jiang, T.·Peng, Y.
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Abstract

Receptor mediated entry is the first step for viral infection. However, the relationship between viruses and receptors is still obscure. Here, by manually curating a high-quality database of 268 pairs of mammalian virus-host receptor interaction, which included 128 unique viral species or sub-species and 119 virus receptors, we found the viral receptors were structurally and functionally diverse, yet they had several common features when compared to other cell membrane proteins: more protein domains, higher level of N-glycosylation, higher ratio of self-interaction and more interaction partners, and higher expression in most tissues of the host. Additionally, the receptors used by the same virus tended to co-evolve. Further correlation analysis between viral receptors and the tissue and host specificity of the virus shows that the virus receptor similarity was a significant predictor for mammalian virus cross-species. This work could deepen our understanding towards the viral receptor selection and help evaluate the risk of viral zoonotic diseases.

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Zhang, Z., Zhu, Z., Chen, W., Cai, Z., Xu, B., Tan, Z., Wu, A., Ge, X., Guo, X., Xia, Z., Zhu, H., Jiang, T., Peng, Y.. 2018-02-25. Membrane proteins with high N-glycosylation, high expression, and multiple interaction partners were preferred by mammalian viruses as receptors. https://doi.org/10.1101/271171

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