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bioRxiv · 10.1101/270876

Probing the network structure of health deficits in human aging

Farrell, S. G.·Mitnitski, A. B.·Theou, O.·Rockwood, K.·Rutenberg, A. D.
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Abstract

Human aging leads to the stochastic accumulation of damage. We model an aging population using a stochastic network model. Individuals are modeled as a network of interacting nodes, representing health attributes. Nodes in the network stochastically damage and repair, with rates dependent on the state of their neighbors. Damaged nodes represent health deficits. The Frailty Index (FI) assesses age-related damage as the proportion of health deficits an individual has accumulated, from a selection of attributes. Here, we use computational, information-theoretic, and mean-field approaches to show that the degree distribution and degree correlations of the underlying network are important to the models ability to recover the behavior of observational health data. We use different measures of damage in the network to probe the structure of the network. We find that the behavior of different classes of observational health deficits (laboratory or clinical) is similar to the behavior of nodes of low or high degree in the model, respectively. This explains how damage can propagate within the network, leading towards individual mortality.

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Farrell, S. G., Mitnitski, A. B., Theou, O., Rockwood, K., Rutenberg, A. D.. 2018-02-23. Probing the network structure of health deficits in human aging. https://doi.org/10.1101/270876

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