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bioRxiv · 10.1101/265959

A new paradigm for personalized cancer screening

Walker, R.·Enderling, H.
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Abstract

A series of distinct histologic lesions precedes the onset of malignancy in many common cancers, yet early detection remains a major challenge. Many patients still experience late (stage IV) diagnoses and thus poor prognosis and limited options for therapeutic intervention. For cancers with known biomarkers of premalignant progression, optimized patient-specific screening protocols would minimize the risk of undetected progression to advanced stage disease. Here, we propose simple, cost-effective mathematical and statistical approaches to forecasting disease progression that could guide the personalization of optimal screening times for high-risk patients.

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Walker, R., Enderling, H.. 2018-02-15. A new paradigm for personalized cancer screening. https://doi.org/10.1101/265959

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