An Augmented Aging Process in Brain White Matter in HIV

Kuhn, T.; Kaufmann, T.; Doan, N. T.; Westlye, L. T.; Jones, J. D.; Nunez, R. A.; Bookheimer, S. Y.; Singer, E. J.; Hinkin, C. H.; Thames, A. D.

doi:10.1101/265199

bioRxiv · 10.1101/265199

An Augmented Aging Process in Brain White Matter in HIV

Kuhn, T.·Kaufmann, T.·Doan, N. T.·Westlye, L. T.·Jones, J. D.·Nunez, R. A.·Bookheimer, S. Y.·Singer, E. J.·Hinkin, C. H.·Thames, A. D.

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Abstract

ObjectiveHIV infection and aging are both associated with neurodegeneration. However, whether the aging process alone or other factors associated with advanced age account for the progression of neurodegeneration in the aging HIV-positive (HIV+) population remains unclear.\n\nMethodsHIV+ (n=70) and HIV-negative (HIV-, n=34) participants underwent diffusion tensor imaging (DTI) and metrics of microstructural properties were extracted from regions of interest (ROIs). A support vector regression model was trained on two independent datasets of healthy adults across the adult life-span (n=765, Cam-CAN = 588; UiO = 177) to predict participant age from DTI metrics, and applied to the HIV dataset. Predicted brain age gap (BAG) was computed as the difference between predicted age and chronological age, and statistically compared between HIV groups. Regressions assessed the relationship between BAG and HIV severity/medical comorbidities. Finally, correlation analyses tested for associations between BAG and cognitive performance.\n\nResultsBAG was significantly higher in the HIV+ group than the HIV-group F (1, 103) = 12.408, p = 0.001). HIV RNA viral load was significantly associated with BAG, particularly in older HIV+ individuals (R2 = 0.29, F(7, 70) = 2.66, p = 0.021). Further, BAG was negatively correlated with domain-level cognitive function (learning: r = -0.26, p = 0.008; memory: r = -0.21, p = 0.034).\n\nConclusionsHIV infection is associated with augmented white matter aging, and greater brain aging is associated with worse cognitive performance in multiple domains.

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Kuhn, T., Kaufmann, T., Doan, N. T., Westlye, L. T., Jones, J. D., Nunez, R. A., Bookheimer, S. Y., Singer, E. J., Hinkin, C. H., Thames, A. D.. 2018-02-14. An Augmented Aging Process in Brain White Matter in HIV. https://doi.org/10.1101/265199

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