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bioRxiv · 10.1101/251579

Local Delivery of Stromal Cell-Derived Factor-1α Improves the Pregnancy Rate of Injured Uterus through the Promotion of Endometrial and Vascular Regeneration

Cai, H.·Wu, B.·Liu, Y.·Li, Y.·Shi, L.·Gong, L.·Xia, Y.·Heng, B.·Wu, H.·Ouyang, H.·Zhu, Z.·Zou, X.
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Abstract

Severe infection and mechanical injury of the uterus may lead to infertility and miscarriage. Currently, there is a lack of effective treatment modality for functional repair of uterine injury. To address this clinical challenge, this study aimed to develop a chemotactic composite scaffold by incorporating recombinant human stromal cell-derived factor-1 (rhSDF-1) into a silk fibroin-bacterial cellulose (SF-BC) membrane carrier. A rat model of uterine injury was utilized for this study, which was composed of three groups: blank control, implantation with SF-BC only or SF-BC loaded with rhSDF-1. The tissue regeneration efficacy of the three groups were analyzed and compared. The results showed that SF-BC loaded with rhSDF-1 significantly enhanced endometrial regeneration and arteriogenesis of the injured rat uterus, which led to improved pregnancy outcomes, thus indicating much promise for functional uterine repair and regeneration.

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Cai, H., Wu, B., Liu, Y., Li, Y., Shi, L., Gong, L., Xia, Y., Heng, B., Wu, H., Ouyang, H., Zhu, Z., Zou, X.. 2018-01-22. Local Delivery of Stromal Cell-Derived Factor-1α Improves the Pregnancy Rate of Injured Uterus through the Promotion of Endometrial and Vascular Regeneration. https://doi.org/10.1101/251579

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