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bioRxiv · 10.1101/251298

Dynamic compensation and homeostasis: a feedback control perspective

Fliess, M.·Join, C.
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Abstract

\"Dynamic compensation\" is a robustness property where a perturbed biological circuit maintains a suitable output [Karin O., Swisa A., Glaser B., Dor Y., Alon U. (2016). Mol. Syst. Biol., 12: 886]. In spite of several attempts, no fully convincing analysis seems now to be on hand. This communication suggests an explanation via \"model-free control\" and the corresponding \"intelligent\" controllers [Fliess M., Join C. (2013). Int. J. Contr., 86, 2228-2252], which are already successfully applied in many concrete situations. As a byproduct this setting provides also a slightly different presentation of homeostasis, or \"exact adaptation,\" where the working conditions are assumed to be \"mild.\" Several convincing, but academic, computer simulations are provided and discussed.

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Fliess, M., Join, C.. 2018-01-23. Dynamic compensation and homeostasis: a feedback control perspective. https://doi.org/10.1101/251298

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