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bioRxiv · 10.1101/245795

Time-scale separation and stochasticity conspire to impact phenotypic dynamics in the canonical and inverted Bacillus subtilis core genetic regulation circuits.

Hao, L.·Yang, Z.·Turcotte, M.
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Abstract

In this work, we study two seemingly unrelated aspects of core genetic nonlinear dynamical control of the competence phenotype in Bacillus subtilis, a common Gram-positive bacterium living in the soil. We focus on hitherto unchartered aspects of the dynamics by exploring the effect of time scale separation between transcription and translation and, as well, the effect of intrinsic molecular stochasticity. We consider these aspects of regulatory control as two possible evolutionary handles. Hence, using theory and computations, we study how the onset of oscillations breaks the excitability-based competence phenotype in two topologically close evolutionary competing circuits: the canonical \"wild-type\" regulation circuit selected by Evolution and, the indirect-feedback inverted circuit that failed to be selected by Evolution, as was shown elsewhere, due to dynamical reasons.

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Hao, L., Yang, Z., Turcotte, M.. 2018-01-10. Time-scale separation and stochasticity conspire to impact phenotypic dynamics in the canonical and inverted Bacillus subtilis core genetic regulation circuits.. https://doi.org/10.1101/245795

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