Global phylogenomics of multidrug-resistant Staphylococcus aureus sequence type 772: the Bengal Bay clone

Steinig, E. J.; Duchene, S.; Robinson, D. A.; Monecke, S.; Yokoyama, M.; Laabei, M.; Slickers, P.; Andersson, P.; Williamson, D.; Kearns, A.; Goering, R.; Dickson, E.; Ehricht, R.; Ip, M.; O'Sullivan, M. V.; Coombs, G. W.; Petersen, A.; Brennan, G.; Shore, A. C.; Coleman, D. C.; Pantosti, A.; de Lencastre, H.; Westh, H.; Kobayashi, N.; Heffernan, H.; Strommenger, B.; Layer, F.; Weber, S.; Aamot, H.; Skakni, L.; Peacock, S. J.; Sarovich, D.; Giffard, P.; Harris, S.; Parkhill, J.; Massey, R. C.; Holden, M. T.; Bentley, S. D.; Tong, S. Y.

doi:10.1101/233395

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bioRxiv · 10.1101/233395

Global phylogenomics of multidrug-resistant Staphylococcus aureus sequence type 772: the Bengal Bay clone

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Abstract

The global spread of antimicrobial resistance has been well documented in Gram-negative bacteria and healthcare-associated epidemic pathogens, often emerging from regions with heavy antimicrobial use. However, the degree to which similar processes occur with Gram-positive bacteria in the community setting is less well understood. Here we demonstrate the recent origin and global spread from the Indian subcontinent of a multidrug resistant Staphylococcus aureus lineage, sequence type 772 (Bengal Bay clone). Short-term outbreaks occurred following intercontinental transmission, typically associated with travel and family contacts, but ongoing endemic transmission was uncommon. Instrumental in the emergence of a single dominant clade in the early 1990s was the acquisition of a multidrug resistance integrated plasmid that did not appear to incur a significant fitness cost. The Bengal Bay clone therefore combines the multidrug resistance of traditional healthcare-associated clones with the epidemiological and virulence potential of community-associated clones.

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Steinig, E. J., Duchene, S., Robinson, D. A., Monecke, S., Yokoyama, M., Laabei, M., Slickers, P., Andersson, P., Williamson, D., Kearns, A., Goering, R., Dickson, E., Ehricht, R., Ip, M., O'Sullivan, M. V., Coombs, G. W., Petersen, A., Brennan, G., Shore, A. C., Coleman, D. C., Pantosti, A., de Lencastre, H., Westh, H., Kobayashi, N., Heffernan, H., Strommenger, B., Layer, F., Weber, S., Aamot, H., Skakni, L., Peacock, S. J., Sarovich, D., Giffard, P., Harris, S., Parkhill, J., Massey, R. C., Holden, M. T., Bentley, S. D., Tong, S. Y.. 2017-12-13. Global phylogenomics of multidrug-resistant Staphylococcus aureus sequence type 772: the Bengal Bay clone. https://doi.org/10.1101/233395

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