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bioRxiv · 10.1101/232678

Phasic Activation of Ventral Tegmental, but not Substantia Nigra, Dopamine Neurons Promotes Model-Based Pavlovian Reward Learning

Abstract

Dopamine (DA) neurons in the ventral tegmental area (VTA) and substantia nigra (SNc) encode reward prediction errors (RPEs) and are proposed to mediate error-driven learning. However the learning strategy engaged by DA-RPEs remains controversial. Model-free associations imbue cue/actions with pure value, independently of representations of their associated outcome. In contrast, model-based associations support detailed representation of anticipated outcomes. Here we show that although both VTA and SNc DA neuron activation reinforces instrumental responding, only VTA DA neuron activation during consumption of expected sucrose reward restores error-driven learning and promotes formation of a new cue[->]sucrose association. Critically, expression of VTA DA-dependent Pavlovian associations is abolished following sucrose devaluation, a signature of model-based learning. These findings reveal that activation of VTA-or SNc-DA neurons engages largely dissociable learning processes with VTA-DA neurons capable of participating in model-based predictive learning, while the role of SNc-DA neurons appears limited to reinforcement of instrumental responses.

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BibTeXRIS

Keiflin, R., Pribut, H. J., Shah, N. B., Janak, P. H.. 2017-12-13. Phasic Activation of Ventral Tegmental, but not Substantia Nigra, Dopamine Neurons Promotes Model-Based Pavlovian Reward Learning. https://doi.org/10.1101/232678

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