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bioRxiv · 10.1101/232546

Similar clinical improvement and maintenance after rTMS at 5 Hz using a simple vs. complex protocol in Alzheimer’s disease

Alcala, R.·Morelos-Santana, E. D.·Cortes-Sotres, J. F.·Garza-Villarreal, E. A.·Sosa, A. L.·Gonzalez-Olvera, J. J.
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Abstract

BrackgroundCurrent treatments for Alzheimers disease (AD) have a limited clinical response and methods, such as repetitive transcranial magnetic stimulation (rTMS), are being studied as possible treatments for the clinical symptoms with positive results. However, there is still seldom information on the type of rTMS protocols that deliver the best clinical improvement in AD.\n\nObjetiveTo compare the clinical response between a simple stimulation protocol on the left dorsolateral prefrontal cortex (lDLPFC) against a complex protocol using six regions of interest.\n\nMethods19 participants were randomized to receive any of the protocols. The analysis of repeated measures evaluated the change.\n\nResultsBoth protocols were equally proficient at improving cognitive function, behavior and functionality after 3 weeks of treatment, and the effects were maintained for 4 weeks more without treatment.\n\nConclusionWe suggest rTMS on the lDLPFC could be enough to provide a clinical response, and the underlying mechanisms should be studied.

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Alcala, R., Morelos-Santana, E. D., Cortes-Sotres, J. F., Garza-Villarreal, E. A., Sosa, A. L., Gonzalez-Olvera, J. J.. 2017-12-13. Similar clinical improvement and maintenance after rTMS at 5 Hz using a simple vs. complex protocol in Alzheimer’s disease. https://doi.org/10.1101/232546

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