Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity

Smit, D. J.; Wright, M. J.; Meyers, J.; Martin, N.; Ho, Y. Y.; Malone, S. M.; Zhang, J.; Burwell, S. J.; Chorlian, D. B.; de Geus, E. J.; Denys, D.; Hansell, N. K.; Hottenga, J.-J.; McGue, M.; van Beijsterveldt, C. E.; Jahanshad, N.; Thompson, P. M.; Whelan, C. D.; Medland, S. E.; Porjesz, B.; Iacono, W. G.; Boomsma, D. I.

doi:10.1101/232330

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bioRxiv · 10.1101/232330

Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity

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Abstract

Oscillations in neuronal activity are widely thought to play a crucial role in information processing and cortical communication 1-8. Brain oscillations have been widely investigated as biomarkers of psychiatric disorders and variation in normal human behavior 9, 10, including intelligence 11, 12, schizophrenia 13, 14, attentional deficits 15, 16, and substance use 17, 18. Beyond the biomarker, oscillatory activity may indeed cause variation in behavior, as it has been shown that disrupting oscillatory activity by blocking GABAergic fast-spiking interneurons in the frontal cortex of mice impairs behavioral flexibility8, consistent with ...

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Smit, D. J., Wright, M. J., Meyers, J., Martin, N., Ho, Y. Y., Malone, S. M., Zhang, J., Burwell, S. J., Chorlian, D. B., de Geus, E. J., Denys, D., Hansell, N. K., Hottenga, J.-J., McGue, M., van Beijsterveldt, C. E., Jahanshad, N., Thompson, P. M., Whelan, C. D., Medland, S. E., Porjesz, B., Iacono, W. G., Boomsma, D. I.. 2017-12-11. Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity. https://doi.org/10.1101/232330

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