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bioRxiv · 10.1101/231340

Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion

Ding, C.·Palmer, C. J.·Hohwy, J.·Youssef, G. J.·Paton, B.·Tsuchiya, N.·Stout, J. C.·Thyagarajan, D.
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Abstract

Parkinsons disease (PD) alters cortico-basal ganglia-thalamic circuitry and susceptibility to an illusion of bodily awareness, the Rubber Hand Illusion (RHI). Bodily awareness is thought to result from multisensory integration in a predominantly cortical network; the role of subcortical connections is unknown. We studied the effect of modulating cortico-subcortical circuitry on multisensory integration for bodily awareness in PD patients treated with subthalamic nucleus (STN) deep brain stimulation (DBS) using the RHI experiment. Typically, synchronous visuo-tactile cues induce a false perception of touch on the rubber hand as if it were the subjects hand, whereas asynchronous visuo-tactile cues do not. However, we found that in the asynchronous condition, patients in the off-stimulation state did not reject the RHI as strongly as healthy controls; switching on STN-DBS partially normalised their responses. Patients in the off-stimulation state also misjudged the position of their hand, indicating it to be closer to the rubber hand than controls. However, STN-DBS did not affect proprioceptive judgements or subsequent arm movements altered by the perceptual effects of the illusion. Our findings support the idea that the STN and subcortical connections have a key role in multisensory integration for bodily awareness. Decisionmaking in multisensory bodily illusions is discussed.

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Ding, C., Palmer, C. J., Hohwy, J., Youssef, G. J., Paton, B., Tsuchiya, N., Stout, J. C., Thyagarajan, D.. 2017-12-11. Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion. https://doi.org/10.1101/231340

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