Antigen-induced but not innate memory CD8 T cells express NKG2D and are recruited to the lung parenchyma upon viral infection

Grau, M.; Valsesia, S.; Mafille, J.; Djebali, S.; Tomkowiak, M.; Mathieu, A.-L.; Laubreton, D.; De bernard, S.; Jouve, P.-E.; Buffat, L.; Walzer, T.; LEVERRIER, Y.; marvel, j.

doi:10.1101/224782

bioRxiv · 10.1101/224782

Antigen-induced but not innate memory CD8 T cells express NKG2D and are recruited to the lung parenchyma upon viral infection

Grau, M.·Valsesia, S.·Mafille, J.·Djebali, S.·Tomkowiak, M.·Mathieu, A.-L.·Laubreton, D.·De bernard, S.·Jouve, P.-E.·Buffat, L.·Walzer, T.·LEVERRIER, Y.·marvel, j.

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Abstract

The pool of memory-phenotype CD8 T cells is composed of antigen-induced (AI) and cytokine-induced innate (IN) cells. IN have been described as having similar properties to AI memory cells. However, we found that pathogen-induced AI memory cells can be distinguished from naturally-generated IN memory cells by surface expression of NKG2D. Using this marker, we described the increased functionalities of AI and IN memory CD8 T cells compared to naive cells, as shown by comprehensive analysis of cytokine secretion and gene expression. However, AI differed from IN memory CD8 T cells by their capacity to migrate to the lung parenchyma upon inflammation or infection, a process dependent on their expression of ITGA1/CD49a and ITGA4/CD49d integrins.

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Grau, M., Valsesia, S., Mafille, J., Djebali, S., Tomkowiak, M., Mathieu, A.-L., Laubreton, D., De bernard, S., Jouve, P.-E., Buffat, L., Walzer, T., LEVERRIER, Y., marvel, j.. 2017-11-25. Antigen-induced but not innate memory CD8 T cells express NKG2D and are recruited to the lung parenchyma upon viral infection. https://doi.org/10.1101/224782

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