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bioRxiv · 10.1101/213967

CalR: A Web-based Analysis Tool for Indirect Calorimetry Experiments

Mina, A. I.·LeClair, R. A.·LeClair, K. B.·Cohen, D. E.·Lantier, L.·Banks, A. S.
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Abstract

We report a web-based tool for analysis of indirect calorimetry experiments which measure physiological energy balance. CalR easily imports raw data files, generates plots, and determines the most appropriate statistical tests for interpretation. Analysis with the general linear model (which includes ANOVA and ANCOVA) allows for flexibility to interpret experiments of obesity and thermogenesis. Users may also produce standardized output files of an experiment which can be shared and subsequently re-evaluated using CalR. This framework will provide the transparency necessary to enhance consistency and reproducibility in experiments of energy expenditure. CalR analysis software will greatly increase the speed and efficiency with which metabolic experiments can be organized, analyzed according to accepted norms, and reproduced--and will likely become a standard tool for the field. CalR is accessible at https://CalR.bwh.harvard.edu.\n\nGraphical Abstract\n\nO_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=138 SRC=\"FIGDIR/small/213967_ufig1.gif\" ALT=\"Figure 1\">\nView larger version (34K):\norg.highwire.dtl.DTLVardef@c27058org.highwire.dtl.DTLVardef@15dbe84org.highwire.dtl.DTLVardef@1870019org.highwire.dtl.DTLVardef@17a17c_HPS_FORMAT_FIGEXP M_FIG C_FIG

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Mina, A. I., LeClair, R. A., LeClair, K. B., Cohen, D. E., Lantier, L., Banks, A. S.. 2017-11-04. CalR: A Web-based Analysis Tool for Indirect Calorimetry Experiments. https://doi.org/10.1101/213967

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