Genetic variation across the human olfactory receptor repertoire alters odor perception

Trimmer, C.; Keller, A.; Murphy, N. R.; Snyder, L. L.; Willer, J. R.; Nagai, M.; Katsanis, N.; Vosshall, L. B.; Matsunami, H.; Mainland, J. D.

doi:10.1101/212431

bioRxiv · 10.1101/212431

Genetic variation across the human olfactory receptor repertoire alters odor perception

Trimmer, C.·Keller, A.·Murphy, N. R.·Snyder, L. L.·Willer, J. R.·Nagai, M.·Katsanis, N.·Vosshall, L. B.·Matsunami, H.·Mainland, J. D.

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Abstract

The human olfactory receptor repertoire is characterized by an abundance of genetic variation that affects receptor response, but the perceptual effects of this variation are unclear. To address this issue, we sequenced the OR repertoire in 332 individuals and examined the relationship between genetic variation and 276 olfactory phenotypes, including the perceived intensity and pleasantness of 68 odorants at two concentrations, detection thresholds of three odorants, and general olfactory acuity. Genetic variation in a single OR frequently associated with odorant perception, and we validated 10 cases in which in vitro OR function correlated with in vivo odorant perception using a functional assay. This more than doubles the published examples of this phenomenon. For eight of these 10 cases, reduced receptor function associated with reduced intensity perception. In addition, we used participant genotypes to quantify genetic ancestry and found that, in combination with single OR genotype, age and gender, we can explain between 10 and 20% of the perceptual variation in 15 olfactory phenotypes, highlighting the importance of single OR genotype, ancestry, and demographic factors in variation of olfactory perception.

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Trimmer, C., Keller, A., Murphy, N. R., Snyder, L. L., Willer, J. R., Nagai, M., Katsanis, N., Vosshall, L. B., Matsunami, H., Mainland, J. D.. 2017-11-01. Genetic variation across the human olfactory receptor repertoire alters odor perception. https://doi.org/10.1101/212431

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