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bioRxiv · 10.1101/2025.11.11.686428

Extracting task-relevant preserved dynamics from contrastive aligned neural recordings

Abstract

Recent work indicates that low-dimensional dynamics of neural and behavioral data are often preserved across days and subjects. However, extracting these preserved dynamics remains challenging: high-dimensional neural population activity and the recorded neuron populations vary across recording sessions. While existing modeling tools can improve alignment between neural and behavioral data, they often operate on a per-subject basis or discretize behavior into categories, disrupting its natural continuity and failing to capture the underlying dynamics. We introduce Contrastive Aligned Neural DYnamics (CANDY), an end-to-end framework that aligns neural and behavioral data using rank-based contrastive learning, adapted for continuous behavioral variables, to project neural activity from different sessions onto a shared low-dimensional embedding space. CANDY fits a shared linear dynamical system to the aligned embeddings, enabling an interpretable model of the conserved temporal structure in the latent space. We validate CANDY on synthetic and real-world datasets spanning multiple species, behaviors, and recording modalities. Our results show that CANDY is able to learn aligned latent embeddings and preserved dynamics across neural recording sessions and subjects, and it achieves improved cross-session behavior decoding performance. We further show that the latent linear dynamical system generalizes to new sessions and subjects, achieving comparable or even superior behavior decoding performance to models trained from scratch. These advances enable robust cross-session behavioral decoding and offer a path towards identifying shared neural dynamics that underlie behavior across individuals and recording conditions. The code and two-photon imaging data of striatal neural activity that we acquired here are available at https://github.com/schnitzer-lab/CANDY-public.git.

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BibTeXRIS

Jiang, Y., Sheng, K., Gao, Y., Buchanan, E. K., Shikano, Y., Kim, T. H., Zhao, Y., Woo, S. J., Dinc, F., Linderman, S. W., Schnitzer, M. J.. 2025-11-13. Extracting task-relevant preserved dynamics from contrastive aligned neural recordings. https://doi.org/10.1101/2025.11.11.686428

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