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bioRxiv · 10.1101/2025.10.14.681560

Auditory Stimulus Information Entropy Modulates Inter-Brain Synchronization: Evidence from Wireless EEG Hyperscanning

Liao, J.·Huang, G.·Zhao, W.·Li, C. X.·Cheng, P. W. C.·Sun, R.·Yuan, H.-Y.·Gao, J.·Ho, R. T. H.
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Abstract

Inter-brain synchronization (IBS) - reflecting inter-individual correlated neural activity during interaction - marks shared experiences like music listening. The ability of complex auditory stimuli (e.g., music) to induce IBS links to their information dynamics, notably the uncertainty they evoke, which challenges the nervous systems predictive coding. Based on mutual prediction theory (interacting individuals simultaneously process their own behavior and predict their partners; accurate mutual predictions lead to convergent neural representations and thus IBS), this study hypothesized that higher stimulus uncertainty enhances IBS (heightened uncertainty reduces independent predictability, promoting convergent representations and stronger IBS). Using information entropy to quantify uncertainty, the study conducted hyperscanning, manipulated entropy across Resting State and 6 Hz auditory stimuli (ASSR, MMN, AHER, Dream Wedding), and measured IBS via phase-locking values (PLV). Results showed frequency specificity: 6 Hz PLV increased with entropy (DW {approx} AHER > MMN {approx} ASSR > Resting State); Alpha band had highest PLV in Resting State. Critically, PLVs differed significantly between any two conditions, and each experimental conditions PLV was also significantly different from that of the Resting State. Findings confirm a 6 Hz-specific positive association between auditory uncertainty and IBS, suggesting musical elements may facilitate social interaction by modulating entropy, with entropy-IBS relations showing frequency dependence.

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Liao, J., Huang, G., Zhao, W., Li, C. X., Cheng, P. W. C., Sun, R., Yuan, H.-Y., Gao, J., Ho, R. T. H.. 2025-10-15. Auditory Stimulus Information Entropy Modulates Inter-Brain Synchronization: Evidence from Wireless EEG Hyperscanning. https://doi.org/10.1101/2025.10.14.681560

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