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bioRxiv · 10.1101/2025.09.29.678190

REDUCED ALPHA-BAND PHASE COHERENCE AND CORTICAL COMPLEXITY IN FIBROMYALGIA: A TMS-EEG EXPLORATORY STUDY

Jakobsen, A.·De Martino, E.·Couto, B. A. N.·Bach, M. M.·Palsson, T. S.·Ingemann-Molden, S.·Blicher, J.·Casali, A. G.·Graven-Nielsen, T.·de Andrade, D. C.
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Abstract

ObjectivesCortico-spinal excitability of the primary motor cortex (M1) is reduced in fibromyalgia, and repetitive transcranial magnetic stimulation (TMS) targeting M1 normalizes these changes and relieves symptoms. TMS combined with electroencephalography (TMS-EEG) allows the measurement of M1 excitability and its connectivity to other regions, which may help clarify neurophysiological effects in fibromyalgia. We assessed cortical excitability, oscillatory activity, and complexity in individuals with fibromyalgia compared to pain-free healthy controls. MethodsGlobal and local mean field power, peak-to-peak amplitude, event-related spectral perturbation, intertrial coherence (ITC), natural frequency, and perturbational complexity index (PCIst) of the EEG response after left-M1 TMS were compared between groups (n=18 fibromyalgia; n=15 controls). Pain intensity, interference, relief of current therapy, mood, and quality of life were assessed in individuals with fibromyalgia. ResultsCompared with controls, individuals with fibromyalgia showed a reduction in the alpha-band ITC in middle and right parieto-occipital areas (P<0.05). Middle-parieto-occipital ITC negatively correlated with reported pain relief (rho=-0.552, p=0.019). The PCIst was lower in fibromyalgia compared with controls (P<0.01) and correlated with higher pain interference in general activity (rho=-0.486, p=0.042). ConclusionIndividuals with fibromyalgia showed abnormal cortical connectivity compared with asymptomatic controls. SignificanceTMS-EEG measurements may provide insights on brain connectivity relevant for therapy.

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Jakobsen, A., De Martino, E., Couto, B. A. N., Bach, M. M., Palsson, T. S., Ingemann-Molden, S., Blicher, J., Casali, A. G., Graven-Nielsen, T., de Andrade, D. C.. 2025-09-30. REDUCED ALPHA-BAND PHASE COHERENCE AND CORTICAL COMPLEXITY IN FIBROMYALGIA: A TMS-EEG EXPLORATORY STUDY. https://doi.org/10.1101/2025.09.29.678190

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