Neural responses to binocular in-phase and anti-phase stimuli

Abstract

Binocular vision fuses compatible inputs from the two eyes into a single percept, whereas incompatible inputs can produce rivalry, lustre, or diplopia. We measured neural responses to binocular stimuli with different phase relationships to test predictions from contemporary binocular combination models. Steady-State Visually Evoked Potentials (SSVEPs) were recorded from 15 observers in response to monocular and binocular stimulation at 3 Hz, using either On/Off or counterphase flicker with varied spatial and temporal phase relationships. On/Off flicker elicited responses at the fundamental frequency (3 Hz), and its integer harmonics, while counterphase flicker generated responses at the even integer harmonics (6Hz, 12Hz, 18Hz). Manipulating phase relationships modulated these response patterns, including a reduction in the fundamental amplitude for On/Off flicker. The data were modelled with a series of binocular combination algorithms, ranging in complexity from a simple linear sum to a two-stage binocular gain-control model with parallel monocular and binocular phase-selective channels. The model required parallel monocular channels to account for our data, whereas phase selectivity was not essential. Overall, the two-stage contrast gain-control model remains a powerful and flexible framework for describing binocular combinations across various experimental conditions and modalities.