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bioRxiv · 10.1101/2025.08.21.671604

The vaginal microbiome drives endometriosis pain

Pratt, M. L.·Manjarres, Z.·Sadler, K. E.
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Abstract

Despite being one of two cardinal disease symptoms, endometriosis pain is poorly understood. Using a validated mouse model, we demonstrate that endometriosis-associated vaginal dysbiosis is sufficient to induce pain in the absence of disease pathology. In addition, intravaginal antibiotic treatment and vaginal microbiome transplant from healthy control animals reverses pain in endometriosis mice.

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Pratt, M. L., Manjarres, Z., Sadler, K. E.. 2025-08-21. The vaginal microbiome drives endometriosis pain. https://doi.org/10.1101/2025.08.21.671604

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